Disphosphonates cardiac uptake in familial amyloid neuropathy: Comparison between DPD and HMDP

نویسندگان

  • Hamza Regaieg
  • Renata De Paola Chequer
  • Rana Ben Azzouna
  • Vincent Algalarrondo
  • Besma Mahida
  • Michel Slama
  • Dominique Le Guludec
  • François Rouzet
چکیده

Background Familial amyloid polyneuropathy (FAP) is a severe hereditary disease, due to production by the liver of a genetic variant transthyretin (TTR) resulting in tissue amyloid deposits. Cardiac involvement is of major prognostic value. Diphosphonate scintigraphy has been proposed as a diagnostic tool for TTR-related cardiac amyloidosis, but there is no consensus on the optimal radiopharmaceutical. Consequently, we compared the cardiac uptake of two 99mTc-labelled tracers: diphosphono-propanedicarboxylic acid (DPD) and hydroxymethylene diphosphonate (HMDP) in patients with TTR-FAP.

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Comparison of MIBG and Diphosphonate scintigraphy in cardiac involvement of aTTR-FAP

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2015